Prof. Yike Guo

Role: Group Leader




Yike Guo is a Professor of Computing Science in the Department of Computing at Imperial College London. He is the founding Director of the Data Science Institute at Imperial College, as well as leading the Discovery Science Group in the department. Professor Guo also holds the position of CTO of the tranSMART Foundation, a global open source community using and developing data sharing and analytics technology for translational medicine.

Professor Guo received a first-class honours degree in Computing Science from Tsinghua University, China, in 1985 and received his PhD in Computational Logic from Imperial College in 1993 under the supervision of Professor John Darlington. He founded InforSense, a software company for life science and health care data analysis, and served as CEO for several years before the company’s merger with IDBS, a global advanced R&D software provider, in 2009.

He has been working on technology and platforms for scientific data analysis since the mid-1990s, where his research focuses on knowledge discovery, data mining and large-scale data management. He has contributed to numerous major research projects including: the UK EPSRC platform project, Discovery Net; the Wellcome Trust-funded Biological Atlas of Insulin Resistance (BAIR); and the European Commission U-BIOPRED project. He is currently the Principal Investigator of the European Innovative Medicines Initiative (IMI) eTRIKS project, a €23M project that is building a cloud-based informatics platform, in which tranSMART is a core component for clinico-genomic medical research, and co-Investigator of Digital City Exchange, a £5.9M research programme exploring ways to digitally link utilities and services within smart cities.

Professor Guo has published over 200 articles, papers and reports. Projects he has contributed to have been internationally recognised, including winning the “Most Innovative Data Intensive Application Award” at the Supercomputing 2002 conference for Discovery Net, and the Bio-IT World “Best Practices Award” for U-BIOPRED in 2014. He is a Senior Member of the IEEE and is a Fellow of the British Computer Society.


KeyNote & Invited Talks (2013-2014)

Big Data Mining for Neuroscience - the 7th INCF Congress on Neuroinformatics, Leiden, invited speaker (The Netherlands, August 2014)

CAS - The Chinese Academy of Sciences, Beijing, invited speaker (China, June 2014)

Annual CLMS Spymposium, UCL’S Bloomsbury Campus, invited speaker (London, June 2014)

BBC Digital Immersion Programme - The Digital Landscape, Imperial West, invited speaker (London, June 2014)

Science Museum - Landscape of Science Curators Workshops, invited speaker. Title: “BigData” (London, June 2014)

The Bioinformatics Strategy Meeting - Proventa International , Radisson Blu, Heathrow, invited speaker. Title “How do you get an ROI from Big Data Analytics” (London, May 2014)

Data, Insight and Futures Event, Royal School of Arts, invoted speaker (London, May 2014)

ISCTM - Symposium on Clinical and Translational Medicine, The Second Military University, Shanghai, invited speaker (China, May 2014)

BioIT World, Seaport World Trade Center, invited speaker and winner of the BioIT World Best Practices Award  (United States, April 2014)

IBM Big Data Analytics colloquium, The Royal Academy of Engineering, Prince Philip House - Topic: Analytics Architecture and Methodology, invited speaker (London, March 2014)

Joint UK-German meeting on imaging in stratified medicine, British Embassy, Wilhelmstrasse, Berlin. Invited speaker, (Germany, March 2014)

Brain Forum 2013, Laylaty Conference Center Jeddah. Title “Big Data for Small Brain” (Saudi Arabia, December 2013)

IEEE BigData 2013, Silicon Valley - Science & Information Conference, session chair (Unites States, October 2013)

ISMB/ECCB 2013 Bioinformatics Conference, Berlin, invited speaker (Germany, July 2013)


External Committiee and Memberships

Senior Member, IEEE - The Institute of Electrical and Electronics Engineer

Member, ISCB - International Society for Computational Biology

Fellow, BCS, The Chartered Institute for IT

CTO, TranSMART Foundation

Committee Member, KDIR, Knowledge Discovery, Knowledge Engineering and Knowledge Management

Member, BIBM - IEEE International Conference on Bioinformatics and Biomedicine

Programme Committe Member, ICDM, Data Mining in Networks

Member, BHI - Biomedical and Health Informatics

Member, CloudCom ’13 & CloudCom ’14

Member, ADVCOMP 2014 - Controlled
Architecture of a MEMS Capacitive Accelerometer in Closed Loop





To introduce concepts and proof techniques of basic set theory. To introduce certain classes of relations and graphs. To introduce algorithm analysis.


Course Leader




The objective is to give students a clear overview of the problems and issues that must be dealt with in 
constructing flexible distributed applications as well as a comprehensive overview of the basic concepts, technologies and theoretical foundation of cloud computing. The emphasis is on the conceptual basis for distributed systems and computer science aspects of cloud computing rather than a detailed study of particular commercial systems and standards. Concepts will be 
illustrated with examples from practical systems and include hands-on experience of building a cloud application.


Course Leader






Journal Papers

Enhancing Cloud Resource Utilisation using Statistical Analysis

International Journal of Cloud Computing and Services Science (IJ-CLOSER) (2014)

Elastic Application Container System: Elastic Web Applications Provisioning

5th IEEE International Conference on Cloud Computing Technology and Science, Bristol, UK, 2013 (CloudCom 2013) (2014)

Elastic algorithms for guaranteeing quality monotonicity in big data mining

In Big Data, 2013 IEEE International Conference on, pp. 45-50. IEEE, 2013 (2014)

Inferring cell-scale signalling networks via compressive sensing

Ian Adcock, Zhiwei Xu, Yike Guo, Xian Yang, and Lei Nie.
PLoS ONE 9(4): e95326 (2014)

Conference Papers

Cloud Resource Monitoring for Intrusion Detection

5th IEEE International Conference on Cloud Computing Technology and Science, Bristol, UK, 2013 (CloudCom 2013) (2014)

An approximation approach to measurement design in the reconstruction of functional MRI sequences

In Brain and Health Informatics, pp. 115-125. Springer International Publishing, 2013 (2014)

Computational infrastructures for data and knowledge management in systems biology, Springer book in Systems Biology, Vol.1: Systems Biology

Georgatos F, Ballereau S, Pellet J, Ghanem M, Price N, Hood L, Boutigny D, Auffray C, Balling R, and Schneider R., and Yike Guo.
Vol.1: Systems Biology (2013) (2013)

Concinnity: A Digital City Exchange Platform

Digital Economy Conference 2013, University of Salford (2013)

Elastic-TOSCA: Supporting Elasticity of Cloud Application in TOSCA

CLOUD COMPUTING 2013, The Fourth International Conference on Cloud Computing (2013)

Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype

Gibeon D, Batuwita K, Osmond M, Heaney LG, Brightling CE, Niven R, Mansur A, Chaudhuri R, Bucknall CE, Rowe A, Bhavsar PK, Chung KF, Menzies-Gow A., and Yike Guo.
Chest 143 (2), 406-414 - 2013 (2013)

Social networking federation: A position paper

Zhou B, Yike Guo, and Chao Wu.
Computers & Electrical Engineering (2012) (2013)

Automating Mass Spectrometry Proteomics Analysis

Fourth International Conference on Bioinformatics and Computational Biology (2012) (2013)

Environmental monitoring via compressive sensing

Proceedings of the Sixth International Workshop on Knowledge from Sensor Data (2012) (2013)

Improving Resource Utilisation in the Cloud Environment using Multivariate Probabilistic Models

2012 IEEE 5th International Conference on Cloud Computing (CLOUD) (2012) (2013)

Introducing a model composition platform for urban energy and transport systems

Koen Van Dam, Aruna Sivakumar, Nilay Shah, John Polak, Yike Guo, and Orestis Tsinalis. (2013)

Computational infrastructures for data and knowledge management in systems biology, Springer book in Systems Biology, Vol.1: Systems Biology:,

Georgatos F, Ballereau S, Pellet J, Ghanem M, Price N, Hood L, Boutigny D, Auffray C, Balling R, Schneider R, and Yike Guo.
Vol.1: Systems Biology (2013)

Enabling cost-aware and adaptive elasticity of multi-tier cloud applications

Han R, Guo L, Osmond M, Moustafa Ghanem, and Yike Guo.
CHEST Journal, Vol:143, 0012-3692, Pages:- (2012)

Programming Directives for Elastic Computing

Dustdar S, Han R, Satzger B, Hong-Linh T, and Yike Guo.
IEEE Internet Computing, Vol:16, ISSN:1089-7801, Pages:72-77 (2012)

Lightweight Resource Scaling for Cloud Applications

2012 12th IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing (2012)

CACSS: Towards a Generic Cloud Storage Service

The 2nd International Conference on Cloud Computing and Services Science, CLOSER 2012 (2012) (2012)

Developing a novel integrated model of p38 MAPK and glucocorticoid signalling pathways

Alex Holehouse, Xian Yang, Ian Adcock, and Yike Guo.
2012 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) (2012)

Delayed switching applied to memristor neural networks

Wang FZ, Helian N, Wu S, Yang X, Lim G, Rashid MM, and Yike Guo.
Journal of Applied Physics, Vol:111, ISSN:0021-8979, Pages (2012)

Elastic Application Container: A Lightweight Approach for Cloud Resource Provisioning

2012 IEEE 26th International Conference on Advanced Information Networking and Applications (AINA) (2012)

The ForeSee (4C) approach for integrative analysis in gene discovery

Munro RE, Kalaitzopoulos D, Grigoriadis A, and Yike Guo.
Methods Mol Biol, Vol:760, Pages:53-71 (2011)

Principles of Elastic Processes

Dustdar S, Satzger B, Truong H-L, and Yike Guo.
IEEE Internet Computing, Vol:15, ISSN:1089-7801, Pages:66-71 (2011)

Detecting insecure person in crowd with human sensor

Procedia Computer Science, Vol:5, 1877-0509, Pages:788-792 (2011)

The design and implementation of a workflow analysis tool.

Curcin V, Moustafa Ghanem, and Yike Guo.
Royal Society of London. Philosophical Transactions A. Mathematical, Physical and Engineering Sciences, Vol:368, ISSN:1364-503X, Pages:4193-4208 (2010)

Consistency, comprehensiveness, and compatibility of pathway databases

Soh D, Dong D, and Yike Guo.
BMC Bioinformatics, Vol:11, ISSN:1471-2105 (2010)

Analysing scientific workflows with Computational Tree Logic

Curcin V, Moustafa Ghanem, and Yike Guo.
Journal of Cluster Computing, Cluster Computing-the Journal of Networks Software Tools and Applications, Vol:12, ISSN:1386-7857 (2009)

Air pollution monitoring and mining based on sensor Grid in London, Sensors

Yajie Ma, Richards M, Hassard J, Moustafa Ghanem, and Yike Guo.
Vol:8, ISSN:1424-8220, Pages:3601-3623 (2008)